Indole 3 Carbinol and Estrogen

research-853474__180By: Marlene Affeld ~

Within the scientific community, a diverse array of medical studies focus on the interaction of Indole 3 carbinol and estrogen. Estrogen, commonly known as the female hormone, is responsible for many of the womanly characteristics that distinguish the species, including breast development, regulation of menstrual cycles, fertility, and a curvaceous figure.

Estrogen Dominance

A balanced level of estrogen in the body is essential for achieving and maintaining fat loss. In both men and premenopausal women, excess estrogen, also known as estrogen dominance, can cause water retention, bloating, toxic fat gain and a broad assortment of medical problems.

In women, with age there is a natural decline in progesterone and testosterone that can lead to an excess of estrogen. Women who take pharmaceutical hormones, whether in the form of birth control pills or hormone-replacement therapy (HRT) can also experience estrogen dominance.

obesity-993126__180We accumulate excess estrogen in our body either by producing too much of it on our own or we acquire it from our diet or from the environment. We are constantly bombarded with toxic estrogen-like compounds, known as xenoestrogens. These toxins are found in foods that contain noxious pesticides, herbicides or growth hormones. Other sources of toxic estrogen include plastic bottles, household cleaning chemicals and industrial or organic pollution in the air we breathe.

Many of these toxins cause water retention and weight gain, which unfortunately, triggers production of more estrogen from our own fat cells. Additional weight accumulation in turn leads to insulin resistance that increases the risk of estrogen dominance.

Premenopausal women with excess estrogen are likely to have a pear-shaped body type, presenting more weight at the hips. In men and menopausal women, excess estrogen presents as an apple shaped body with the fat accumulation centered in the abdominal area. Medical experts advise that excess estrogen is as much a risk factor for obesity in both men and women as lack of exercise and poor diet.

Persons with estrogen dominance often complain of mood swings, depress, weight gain, water retention, fatigue, insomnia, memory loss, hormonal headaches, and lack of energy and stamina. Other complaints include loss of libido, erectile dysfunction and premature ejaculation and infertility.

What Is Indole-3-Carbinol?

Indole 3 Carbinol (also referred to as I3C) is a member of the glucosinolates family, a group of compounds that also contains other indoles and isothiocyanates, such as sulphoraphane.

plant-690051_640Present in a host of different sulfur-rich cruciferous vegetables such as kale, onions, garlic, Bok choi, watercress, radishes, turnips, mustard greens, collard greens, cauliflower, cabbage, and broccoli, Indole 3 carbinol is an important micronutrient that helps prevent estrogen-enhanced cancers. Indole 3 carbinol is also found in the spice cardamom. I3C is derived from the foods we eat and is also manufactured in the laboratory. An extract from cruciferous vegetables is a manufactured as a dietary supplement, a slightly altered version of the indole 3 carbinol obtained from our diets.

Indole-3-carbinol is used for a diverse array of medical issues. Besides helping to balance out hormonal levels, I3C helps bolster the immune system and has been useful impeding estrogen receptors in breast membranes, helping to lower the risk of breast cancer.

Scientists, studying the connection between Indole 3 Carbinol and estrogen, discovered that the metabolism of estrogen happens by two separate pathways. The first or initial metabolic pathway, 16 alpha-hydroxylation, or the second, healthiest metabolic pathway, 2-hydroxylation. I3C encourages estrogen to take the health-promoting pathway (2-hydroxylation), a pathway that processes estrogen into an anti-estrogen. Because testosterone changes to estrogen in the male body, Indole 3 carbinol can help support estrogen balance in men who take testosterone precursors.

To offset estrogen dominance, athletes, body builders, weight lifters and dieters endeavor to step up their intake of cruciferous veggies by adding them to smoothies, salads, soups, sauces and stir-fry dishes. If you suspect that you may be experiencing estrogen dominance, talk to your doctor to have your hormone levels evaluated. If you are following a diet that does not provide enough natural I3C, your doctor, in addition to advising you to add more vegetables to your daily diet, can recommend the correct dosage of Indole 3 carbinol that is appropriate for your sex, age, weight, current physical condition, and fitness goals.

Indoles, isothiocyanates and sulphoraphanes are all strong antioxidants and natural detoxifying enzymes. Sulphoraphanes have also demonstrated powerful anti-cancer properties. Indoles and isothiocyanates are antioxidants that can naturally neutralize free radicals. I3C also demonstrates an ability to support the liver’s detoxification processes as well as encouraging normal cellular reproduction.

Indole-3-carbinol is changed in the stomach to diindolylmethane (DIM). When indole 3 carbinol supplements are ingested, there is little or no indole 3 carbinol found in the bloodstream. The substance that is found in the bloodstream after ingesting an indole 3 carbinol supplement is DIM, diindolylmethane.

Indole # Carbinol Kills Cancer Cells

Indole-3-carbinol and estrogen research projects have produced a broad base of data that indicates I3C works as a potential cancer preventive. In clinical trials, dosages of 300-400 mg daily converted approximately 50 percent of some stronger estrogens to weaker estrogens in healthy men and women.

In clinical trials conducted at the Jewish Research Institute in Manhasset, New York, scientists achieved promising results, reporting, “Studies increasingly indicate that dietary indole-3-carbinol (I3C) prevents the development of estrogen-enhanced cancers including breast, endometrial and cervical cancers. Epidemiological, laboratory, animal and translational studies support the efficacy of I3C. Whereas estrogen increases the growth and survival of tumors, I3C causes growth arrest and increased apoptosis and ameliorates the effects of estrogen.”

The Oxford Journal of the National Cancer Institute explains, stating, “The oxidative metabolism of estrogens in humans is mediated primarily by cytochrome P450, many isoenzymes of which are inducible by dietary and pharmacologic agents. One major pathway, 2-hydroxylation, is induced by dietary indole-3-carbinol (I3C).”

#StrongerEstrogens  #Estrogenefficacy  #Indole3Carbinol  #estrogenehnancedcancers

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